Plasma protein binding displacement interactions-why are they still regarded as clinically important?

Micrometastases in neuroblastoma: are they clinically important?

Despite advances in the treatment of neuroblastoma (NBL), recurrence and metastases continue to pose major problems in clinical management. The relation between micrometastases and the development of secondary disease is not fully understood. However, accurate methods to detect low numbers of tumour cells may allow the evaluation of their role in the disease process, and by implication the poss...

Observational studies: why are they so important?

What Are Neural Stem Cells, and Why Are They Important?

1Centre for Biomedical Research, University of Victoria, Victoria, BC, Canada, 2Division of Medical Sciences, University of Victoria, Victoria, BC, Canada, 3Island Medical Program, Department of Cellular and Physiological Sciences, The University of British Columbia, Victoria, BC, Canada, 4Department of Mechanical Engineering, University of Victoria, Victoria, BC, Canada, 5International Collabo...

Needs Assessment Competencies: Are They Important for Extension Educators?

The purpose of this study was to determine the importance of eleven professional competencies related to needs assessment and program development; a secondary purpose was to identify the best time these competencies should be learned. The study followed a survey research design, in which 441 randomly selected extension educators in the North Central Region of the United States responded to a qu...

Mechanisms of protein binding to DNA: statistical interactions are important.

Protein molecules binding to DNA initiate sequences of biochemical transitions that control and regulate all major processes in living cells (1). It has long been understood that the efficient transfer of genetic information is possible when genome-regulating protein molecules are found to be strongly bound to special sequences on DNA, known as specific binding sites. It was later realized that...